Differences between renal effects of venom from two Bothrops jararaca populations from southeastern and southern Brazil

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• 作者：Roberta Jeane Bezerra Jorge^a ; ^{robertajeanebj@gmail.com} ; Antô ; nio Rafael Coelho Jorge^b ; Ramon Ró ; seo Paula Pessoa Bezerra de Menezes^b ; Clarissa Perdigã ; o Mello^c ; Danya Bandeira Lima^c ; Joã ; o Alison de Moraes Silveira^b ; Natacha Teresa Queiroz Alves^b ; Aline Diogo Marinho^b ; Rafael Matos Ximenes^d ; Carlos Corrê ; a-Netto^e ; Larissa Gonç ; alves Machado^e ; Russolina Benedeta Zingali^e ; Alice Maria Costa Martins^c ; Helena Serra Azul Monteiro^b
• 关键词：Bothrops jararaca venom ; Renal effects ; MDCK ; Isolated kidney perfusion
• 刊名：Toxicon
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：84-90
• 全文大小：1449 K
• 卷排序：125

文摘

Bothrops jararaca venoms from south and southeast Brazil have different renal effects. B. jararaca venom (Bjv) from south is more nephrotoxic than from Bjv from southeast. Bjv from south showed characteristics of renal injury on isolated kidney. Bjv from southeast showed a diuretic effect on isolated kidney. Bjv from south showed a higher necrotic profile than Bjv from southeast in MDCK cells.