Targeted inhibition of WRN helicase, replication stress and cancer

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• 作者：Natalie Orlovetskie^a ; Raphael Serruya^a ; Ghada Abboud-Jarrous^b ; ^{ghadaj@ekmd.huji.ac.il} ; Nayef Jarrous^a ; ^{jarrous@md.huji.ac.il}
• 关键词：WRN helicase ; RNase P ; EGS ; Selective cancer therapy ; Replication stress ; DNA repair
• 刊名：Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1867
• 期：1
• 页码：42-48
• 全文大小：1387 K
• 卷排序：1867

文摘

Adaptive resistance of cancer is often acquired and inherited by genetic changes. Current targeted therapies lack clinical steps aimed to preclude genetic changes. Depletion of WRN/RecQ helicases triggers replication stress and cell death. For future targeted therapies, WRN/RecQ depletion may diminish adaptive resistance.