Evaluation of mutagenicity of acrylamide using RBC Pig-a and PIGRET assays by single peroral dose in rats
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- 作者：Katsuyoshi Horibata ; horibata@nihs.go.jp ; Akiko Ukai ; Masamitsu Honma
- 关键词：%RET ; percent of reticulocyte ; AA ; acrylamide ; APC ; allophycocyanin ; ENU ; N-ethyl-N-nitrosourea ; FITC ; fluorescein isothiocyanate ; GA ; glycidamide ; GPI ; glycosylphosphatidylinositol ; HSC ; hematopoietic stem cell ; JEMS ; the Japanese Environmental Mutagen Society ; LD50 ; median lethal dose ; MN ; micronucleus ; MF ; mutant frequency ; MMS ; Mammalian Mutagenicity Study Group ; PBS ; phosphate-buffered saline ; PE ; phycoerythrin ; PNH ; paroxysmal nocturnal hemoglobinuria ; RBC ; red blood cell ; RET ; reticulocyt
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：811
- 期：Complete
- 页码：54-59
- 全文大小：689 K
- 卷排序：811
文摘
Usefulness of the PIGRET assay for a short-term genotoxicity test was evaluated. Genotoxicity of acrylamide was examined by the PIGRET assay as a part of joint study. No acrylamide genotoxicity was demonstrated by the PIGRET and RBC Pig-a assays. Our findings using adult male rats are consistent with other reports. Detailed analyses with different age, sex, and species are needed in future.