Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis
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- 作者：Minhee Kim1 ; 2 ; Brian P. O&rsquo ; Rourke1 ; Rajesh Kumar Soni3 ; Prasad V. Jallepalli4 ; Ronald C. Hendrickson3 ; Meng-Fu Bryan Tsou1 ; 2 ; tsoum@mskcc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：16
- 期：5
- 页码：1195-1203
- 全文大小：2599 K
文摘
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Persistent PLK4 is required to stabilize the cartwheel and newborn centrioles
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Phosphomimetic STIL requires active PLK4 to support centriole duplication
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Phosphomimetic STIL can bypass the requirement of PLK4 for cartwheel maintenance
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Loss of intact cartwheel induces stochastic reduplication of mother centrioles