HmGlu_1d, a novel splice variant of the human type I metabotropic glutamate receptor

详细信息    查看全文

• 作者：Laurie ; David J. ; Boddeke ; Hendrikus W.G.M. ; Hiltscher ; Raphaela ; Sommer ; Bernd
• 关键词：Human mGlu_1d ; Metabotropic glutamate receptor ; Ca²⁺ fluorescence
• 刊名：European Journal of Pharmacology
• 出版年：1996
• 出版时间：January 25, 1996
• 年：1996
• 卷：296
• 期：2
• 页码：R1-R3
• 全文大小：221 K

文摘

A novel splice variant, hmGlu_1d, of the human mGlu₁ metabotropic glutamate receptor has been isolated from a human brain library. This clone is identical to human mGlu_1a except that it lacks 35 nucleotides in the 3′ coding sequence, which predicts a truncated protein and a novel carboxy terminus. After injection of the encoding sequence into mouse A9 fibroblasts, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) elicited concentration-dependent increases in intracellular Ca²⁺ (pEC50 values of 6.09 and 4.33, respectively).