Busulfan Triggers Intrinsic Mitochondrial-Dependent Platelet Apoptosis Independent of Platelet Activation
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- 作者：Jianlin Qiao1 ; 2 ; 3 ; &dagger ; ; Yulu Wu1 ; 3 ; &dagger ; ; Yun Liu4 ; Xiaoqian Li1 ; 3 ; Xiaoqing Wu1 ; 3 ; Na Liu5 ; Feng Zhu2 ; Kunming Qi2 ; Hai Cheng2 ; Depeng Li2 ; Hongchun Li4 ; Zhenyu Li2 ; Lingyu Zeng1 ; 2 ; 3 ; Ping Ma4 ; pingm62@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Kailin Xu1 ; 2 ; 3 ; lihmd@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Busulfan ; Platelets ; Mitochondrion ; Apoptosis ; Platelet activation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：22
- 期：9
- 页码：1565-1572
- 全文大小：1762 K
文摘
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Increased mitochondrial membrane depolarization in busulfan-treated platelets
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Busulfan-induced decreased expression of Bcl-2, increased expression of Bax, and caspase 3 activation in platelets
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No platelet activation induced by busulfan
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Busulfan reduced collagen- or adenosine diphosphate–induced platelet aggregation without affecting levels of glycoprotein Ibα, glycoprotein VI, and <alpha>IIb<beta>3
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Busulfan reduced circulating platelet lifespan in mice