Positive Rate of Different Hepatitis B Virus Serological Markers in Peking Union Medical College Hospital, a General Tertiary Hospital in Beijing

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• 作者：Yue-qiu Zhang^a ; ^&dagger ; ; Sai-nan Bian^a ; ^&dagger ; ; Xiao-qing Liu^a ; ^b ; ^{liuxqpumch@126.com" class="auth_mail" title="E-mail the corresponding author} ; Shao-xia Xu^c ; Li-fan Zhang^a ; ^b ; Bao-tong Zhou^a ; Wei-hong Zhang^c ; Yao Zhang^b ; Ying-chun Xu^c ; Guo-hua Deng^a
• 关键词：hepatitis B virus infection ; positive rate ; hepatitis B virus serological markers ; demographic factors
• 刊名：Chinese Medical Sciences Journal
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：31
• 期：1
• 页码：17-22

文摘

To investigate the positive rate of different hepatitis B virus (HBV) serological markers, and the demographic factors related to HBV infection.

Methods

We enrolled all patients tested for HBV serological markers, such as HBV surface antigen (HBsAg), HBV surface antibody (HBsAb), hepatitis B e antigen (HBeAg), hepatitis B e antibody (HBeAb), HBV core antibody (HBcAb), and HBV-DNA from July 2008 to July 2009 in Peking Union Medical College Hospital. The positive rate of each HBV serological marker was calculated according to gender, age, and department, respectively. The positive rates of HBV-DNA among patients with positive HBsAg were also analyzed.

Results

Among 27 409 samples included, 2681 (9.8%) were HBsAg positive. When patients were divided into 9 age groups, the age-specific positive rate of HBsAg was 1.2%, 9.6%, 12.3%, 10.9%, 10.3%, 9.7%, 8.0%, 5.8%, and 4.3%, respectively. The positive rate of HBsAg in non-surgical department, surgical department, and health examination center was 16.2%, 5.8%, and 4.7%, respectively. The positive rate of HBsAg of males (13.3%) was higher than that of females (7.3%, P=0.000). Among the 2681 HBsAg (+) patients, 1230 (45.9%) had HBV-DNA test, of whom 564 (45.9%) were positive. Patients with HBsAg (+), HBeAg (+), and HBcAg (+) result usually had high positive rate of HBV-DNA results (71.8%, P=0.000).

Conclusions

Among this group of patients in our hospital, the positive rate of HBsAg was relatively high. Age group of 20-29, males, and patients in non-surgical departments were factors associated with high positive rate of HBsAg.