Clinical research challenges in rare tumors can be overcome by global data sharing.

The CHIC Collaboration (CHIC) addressed this challenge by combining the data of published clinical trials in hepatoblastoma.

PRETEXT, vascular involvement, extrahepatic disease, tumor multifocality and rupture affect poor outcome in hepatoblastoma.

Higher age (>8 years), low AFP (<100 ng/ml) and metastatic disease are associated with the worst outcome.

The CHIC database is a valuable resource and represents a template to for others to follow in the research of rare tumors.