In vivo targeting of c-Met using a non-standard macrocyclic peptide in gastric carcinoma

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• 作者：Do Won Hwang^a ; ^b ; ¹ ; Namryeong Bahng^a ; ^b ; ^c ; ¹ ; Kenichiro Ito^d ; Seunggyun Ha^a ; ^b ; Mee Young Kim^a ; ^e ; Eunji Lee^a ; Hiroaki Suga^d ; ^{hsuga@chem.s.u-tokyo.ac.jp} ; Dong Soo Lee^a ; ^b ; ^{dsl@snu.ac.kr}
• 关键词：c-Met (hepatocyte growth factor receptor) ; Random non-standard Peptides Integrated Discovery (RaPID) ; Fluorescence-labeled macrocyclic c-Met peptide ; Cancer targeting study ; Tumor receptor imaging
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：144-149
• 全文大小：1401 K
• 卷排序：385

文摘

The c-Met-targeting peptide was designed as non-standard macrocyclic form. The fluorescein-labeled macrocyclic peptides with optimal dose and time were bound in c-Met positive gastric cancer cells. The peptides specifically targeted c-Met-expressing gastric cancers in vivo.