- 作者：Sergio D¨ªaz-Leines ; Yol ; a R. Pe?aloza-L¨®pez ; Tirzo A. Serrano-Mir ; a ; Blanca Flores-¨¢valos ; Martha T. Vidal-Ixta ; Blanca Jim¨¦nez-Herrera
- 关键词：Homocisteí ; na ; Adulto mayor ; Desorden de procesamiento auditivo central ; Potenciales evocados auditivos de tallo cerebral ; Potenciales relacionados a eventos P300
- 刊名：Acta Otorrinolaringol¨®gica Espa?ola
- 出版年：2013
- 出版时间：July-August, 2013
- 年：2013
- 卷：64
- 期：4
- 页码：265-272
- 全文大小：334 K
Introduction and objectives
Hyperhomocysteinemia as a risk factor for hearing impairment, neuronal damage and cognitive impairment in elderly patients is controversial and is limited by the small number of studies.
The aim of this work was determine if elderly patients detected with hyperhomocysteinemia have an increased risk of developing abnormalities in the central auditory processes as compared with a group of patients with appropriate homocysteine levels, and to define the behaviour of psychoacoustic tests and long latency potentials (P300) in these patients.
Methods
This was a cross-sectional, comparative and analytical study. We formed a group of patients with hyperhomocysteinemia and a control group with normal levels of homocysteine. All patients underwent audiometry, tympanometry and a selection of psychoacoustic tests (dichotic digits, low-pass filtered words, speech in noise and masking level difference), auditory evoked brainstem potentials and P300.
Results
Patients with hyperhomocysteinemia had higher values in the test of masking level difference than did the control group (
Conclusions
Hyperhomocysteinemia is a factor that alters the central auditory functions. Alterations in psychoacoustic tests and disturbances in electrophysiological tests suggest that the central portion of the auditory pathway is affected in patients with hyperhomocysteinemia.