Palladium(II)-catalyzed heterocyclisation of 8-arylethynyl-1,2,3,4-tetrahydroquinolines: a facile route to 2-aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline derivatives

详细信息    查看全文

• 作者：Marchand ; Pascal ; Puget ; Alain ; Baut ; Guillaume Le ; Emig ; Peter ; Czech ; Michael ; Gü ; nther ; Eckhard
• 关键词：5 ; 6-Dihydro-4H-pyrrolo[ ; 3 ; 2 ; 1-ij] ; quinolines ; 1 ; 2 ; 3 ; 4-Tetrahydroquinolines ; Palladium(II)-catalyzed intramolecular heterocyclisation
• 刊名：Tetrahedron
• 出版年：2005
• 出版时间：April 18, 2005
• 年：2005
• 卷：61
• 期：16
• 页码：4035-4041
• 全文大小：175 K

文摘

Dihydropyrroloquinolines have been synthesized reacting 8-arylethynyl-1,2,3,4-tetrahydroquinolines in the presence of palladium(II) chloride catalyst. Heteroannulation has been achieved in good yields and tolerates substituents on the tetrahydroquinoline, including bromo, cyano, and ester.