Carcinogenicity and mode of action evaluation for alpha-hexachlorocyclohexane: Implications for human health risk assessment
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- 作者：Ann E. Bradley ; abradley@integral-corp.com" class="auth_mail" title="E-mail the corresponding author ; Joanna L. Shoenfelt ; Judi L. Durda
- 关键词：Alpha-hexachlorocyclohexane ; Hexachlorocyclohexane ; Mode of action ; Human relevance ; Reference dose ; Liver carcinogenesis ; Nonlinear ; Threshold ; Dose-response
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：152-173
- 全文大小：485 K
文摘
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The WOE supports a nonlinear, threshold dose-response for alpha-HCH carcinogenicity.
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Alpha-HCH causes liver tumors in rats and mice through an MOA involving mitogenesis.
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We establish a nonlinear RfD for alpha-HCH of 0.002 mg/kg-day that is protective of chronic exposure to humans.
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Given its regulatory focus, agencies should review the evidence that alpha-HCH acts as a threshold based toxicant.