Effects of the polysaccharides extracted from Ganoderma lucidum on chemotherapy-related fatigue in mice

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• 作者：Ming-zi Ouyang^a ; ^b ; Li-zhu Lin^a ; ^b ; ^{lizhulin903@139.com" class="auth_mail" title="E-mail the corresponding author} ; Wen-jiao Lv^a ; ^b ; Qian Zuo^a ; ^b ; Zhuo Lv^a ; ^b ; Jie-shan Guan^a ; Shu-tang Wang^a ; Ling-ling Sun^a ; Han-rui Chen^a ; Zhi-wei Xiao^a
• 关键词：GLPs ; G. lucidum polysaccharides ; NCG ; the normal control group ; TCG ; the tumor control group ; GLP-LG ; the low-dose GLP group ; GLP-MG ; the middle-dose GLP group ; GLP-HG ; the high-dose GLP group ; PCG ; the cisplatin control group ; GLP-L&#xA0 ; +&#xA0 ; PG ; the low-dose GLP&#xA0 ; +&#xA0 ; cisplatin group ; GLP-M&#xA0 ; +&#xA0 ; PG ; the middle-dose GLP&#xA0 ; +&#xA0 ; cisplatin group ; GLP-L&#xA0 ; +&#xA0 ; PG ; the high-dose GLP&#xA0 ; +&#xA0 ; cisplatin group ; TNF-α ; tumor necrosis factor-α ; IL-6 ; interleukin-6 ; IL-1β ; int
• 刊名：International Journal of Biological Macromolecules
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：91
• 期：Complete
• 页码：905-910
• 全文大小：968 K

文摘

The weight-loaded swimming capability, tumor growth, survival time and biochemical markers of Ganoderma lucidum polysaccharides (GLPs) in a chemotherapy-related fatigue mouse model were tested in the present study. The results showed that the middle-dose GLPs (GLP-M) and the high-dose GLPs (GLP-H) could increase the exhausting swimming time, which was observed to decrease in the cisplatin control group(PCG) and the tumor control group (TCG).The GLP-M and the GLP-H had reduced serum levels of tumor necrosis factor-αand interleukin-6, which were up-regulated by cisplatin. Cisplatin and the presence of tumor significantly enhanced the malondialdehyde (MDA) content and inhibited the activity of superoxide dismutase (SOD) in the muscle. Administration of GLPs at a high dose decreased the levels of MDA and up-regulated the SOD activity. The high-dose GLPs + cisplatin group presented a decreased tendency of tumor volume and a lower tumor weight compared with PCG. Moreover, the mice in the GLP-M and GLP-H groups had longer survival times compared with the mice in the TCG and PCG.The levels of creatinine and serum blood urea nitrogen, which are up-regulated by cisplatin, were significantly reduced by GLP-M and GLP-H. Therefore, these results suggest that GLPs might improve chemotherapy-related fatigue via regulation of inflammatory responses, oxidative stress and reduction of nephrotoxicity.