Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?

详细信息    查看全文

• 作者：Lournaris Torres-Santiago ; M.D.^a ; Nelly Mauras ; M.D.^a ; Jobayer Hossain ; Ph.D.^b ; Arthur L. Weltman ; Ph.D.^c ; Dominique Darmaun ; M.D. ; Ph.D.^a ; ^d ; ^{Ddarmaun@nemours.org}
• 关键词：Amino acids ; Exercise ; Hypoglycemia ; Hyperinsulinemic-euglycemic clamp clamp ; Stable isotopes ; GLP-1
• 刊名：Nutrition
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：Complete
• 页码：1-6
• 全文大小：695 K
• 卷排序：34

文摘

In adolescents with type 1 diabetes with no residual insulin secretion, oral glutamine supplementation increased the incidence of postexercise, nocturnal hypoglycemia compared with a calorie- and nitrogen-free placebo. Insulin sensitivity, as measured using a two-dose hyperinsulinemic-euglycemic clamp clamp the following morning, did not differ between oral glutamine and placebo. Whether long-term oral glutamine would have a role as an oral supplement to affect glucose control remains to be explored.