Structure of the EndoMS-DNA Complex as Mismatch Restriction Endonuclease
详细信息 查看全文
- 作者：Setsu Nakae1 ; Atsushi Hijikata1 ; Toshiyuki Tsuji1 ; Kouki Yonezawa1 ; Ken-ichi Kouyama1 ; Kouta Mayanagi2 ; Sonoko Ishino3 ; Yoshizumi Ishino3 ; Tsuyoshi Shirai1 ; 4 ; t_shirai@nagahama-i-bio.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA repair ; DNA metabolism ; protein-protein interaction ; protein modeling ; structural bioinformatics
- 刊名：Structure
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：24
- 期：11
- 页码：1960-1971
- 全文大小：4584 K
文摘
- •
EndoMS (NucS) is a restriction enzyme that is active on mismatched dsDNA
- •
EndoMS (NucS) undergoes a large conformational change in binding to dsDNA
- •
EndoMS (NucS)-PCNA-dsDNA complex structure was elucidated
- •
EndoMS (NucS) might be involved in a DNA mismatch repair pathway