15-Deoxy-Δ^12,14-prostaglandin J₂ induced neurotoxicity via suppressing phosphoinositide 3-kinase

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• 作者：Hiromi Koma ; Yasuhiro Yamamoto ; Ayaka Nishii ; Tatsurou Yagami ; ^{yagami@himeji-du.ac.jp}
• 关键词：15-Deoxy-Δ12 ; 14&ndash ; prostaglandin J2 ; Phosphoinositide 3-kinase ; Neurotoxicity ; Cerebral cortex ; Hippocampus ; Memory retrieval
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：416-425
• 全文大小：2247 K
• 卷排序：113

文摘

15d-PGJ2 exhibited cytotoxicity via inhibiting the PI3K signaling in primary neurons. PI3K was required for neuronal survival throughout maturation regardless serum. PI3K activator prevented neurons from undergoing the 15d-PGJ2-induced cell death. Injection of 15d-PGJ2 into hippocampus impaired contextual memory retrieval. PI3K activator suppressed the 15d-PGJ2-impaired hippocampal memory retrieval.