HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread

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• 作者：Alice C.L. Len¹ ; Shimona Starling¹ ; Maitreyi Shivkumar¹ ; Clare Jolly¹ ; ² ; ^{c.jolly@ucl.ac.uk}
• 关键词：HIV ; T cell ; signaling ; TCR ; phosphoproteomics ; synapse
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：1062-1074
• 全文大小：3933 K
• 卷排序：18

文摘

Unbiased global analysis of T cell signaling changes during HIV-1 cell-cell spread Experimental system to map dynamic signaling changes in mixed cell populations over time More than 200 host cell proteins are modified as HIV-1 disseminates between T cells HIV-1 activates antigen-independent TCR signaling to drive viral spread