Cell membrane modulation as adjuvant in cancer therapy

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• 作者：Sara Zalba ; ^{s.zalbaoteiza@erasmusmc.nl} ; Timo L.M. ten Hagen
• 关键词：HMG-CoA reductase ; 3-hydroxy-methylglutaryl CoA reductase ; Emodin ; 3-methyl-1 ; 6 ; 8-trihydroxyanthraquinone ; CL ; Cardiolipin ; Cer ; ceramide ; Ch ; cholesterol ; DAG ; Diacylglycerol ; ER ; endoplasmic reticulum ; EGFR ; epidermal growth factor receptor ; EGCG ; epigallocatechin gallate ; FADD ; Fas-Associated protein with Death Domain ; So ; gel solid-ordered state ; GCS ; Glucosylceramide synthase ; IP3 ; inositol 1 ; 4 ; 5-triphosphate ; IGF-1 ; insulin-like receptor ; Ld ; liquid-disordered state ; Lo ; liquid-ordered sta
• 刊名：Cancer Treatment Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：52
• 期：Complete
• 页码：48-57
• 全文大小：1835 K
• 卷排序：52

文摘

Membrane lipid composition is strongly related with membrane functionality and therefore with individual cell role within tissues. Lipid alterations are found in cancer cells with variations between stage and cancer type. Cancer treatment can be improved when combined with lipid modulation strategies. Deeper evaluation of lipid composition in cancer will be useful as predictive/prognostic tool in the near future.