The human endogenous retrovirus K(HML-2) has a broad envelope-mediated cellular tropism and is prone to inhibition at a post-entry, pre-integration step
详细信息 查看全文
- 作者：Philipp Kramer1 ; Veronika Lausch1 ; Alexander Volkwein ; Kirsten Hanke ; Oliver Hohn ; Norbert Bannert ; BannertN@rki.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human endogenous retrovirus ; HERV-K ; Tropism ; Virus entry ; Receptor ; Envelope ; Betaretrovirus
- 刊名：Virology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：487
- 期：Complete
- 页码：121-128
- 全文大小：1004 K
文摘
- ass="listitem" id="list_li0005">
- ass="label">•
We show that HERV-K(HML-2) has a broad cell and tissue tropism.
- ass="label">•
We demonstrate that HERV-K(HML-2) has a broad species tropism.
- ass="label">•
HERV-K(HML-2) does not use the receptors of MMTV and JSRV for entry.
- ass="label">•
We identify a post-entry, pre-integration inhibition of HERV-K(HML-2).
- ass="label">•
We identify early RT products in cells infected with HERV-K(HML-2).
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |