Developmental trajectories of cerebral blood flow and oxidative metabolism at baseline and during working memory tasks
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- 作者：Mayank A. Joga ; 1 ; Lirong Yana ; 1 ; Emily Kilroya ; Kate Krasilevaa ; Kay Janna ; Holly LeClairb ; David Elashoffb ; Danny J.J. Wanga ; jwang71@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Developmental fMRI ; Working memory ; Cerebral blood flow (CBF) ; Cerebral metabolic rate of oxygen consumption (CMRO2) ; Neurovascular coupling
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：134
- 期：Complete
- 页码：587-596
- 全文大小：1493 K
文摘
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Functional brain development was studied using 4 quantitative MRI techniques.
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CBF, OEF and CMRO2 were assessed at baseline and during working memory task.
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Resting CBF and CMRO2 showed an age related decline while global OEF was stable.
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Working memory induced relative CMRO2 change declines with age in sub-regions.
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Brain may become more “energy efficient” with age during development.