Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function
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- 作者：Andrew J. Kennedy1 ; 2 ; Elizabeth J. Rahn1 ; Brynna S. Paulukaitis1 ; 5 ; Katherine E. Savell1 ; Holly B. Kordasiewicz3 ; Jing Wang1 ; John W. Lewis1 ; Jessica Posey1 ; Sarah K. Strange1 ; Mikael C. Guzman-Karlsson1 ; Scott E. Phillips1 ; Kyle Decker1 ; S. Timothy Motley4 ; Eric E. Swayze3 ; David J. Ecker4 ; Todd P. Michael4 ; Jeremy J. Day1 ; J. David Sweatt1 ; 5 ; 6 ; david.sweatt@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：epigenetics ; Pitt-Hopkins syndrome ; transcription factor 4 ; E2-2 ; neuroepigenetics ; DNA methylation ; learning and memory ; next-generation sequencing ; HDAC inhibitor ; schizophrenia ; language ; transcription ; autism ; social interactions ; autism spectrum disorder
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2666-2685
- 全文大小：3561 K
文摘
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A Tcf4(+/−) mouse model is reported for Pitt-Hopkins syndrome (PTHS)
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HDAC inhibition rescues learning and memory deficits of PTHS mice
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Hdac2 is a therapeutic target for cognitive enhancement
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Genes with altered mRNA and CpG Me due to learning are dysregulated in PTHS