The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

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• 作者：Francesca Bernassola ; Michael Karin ; Aaron Ciechanover ; Gerry Melino
• 刊名：Cancer Cell
• 出版年：2008
• 出版时间：8 July 2008
• 年：2008
• 卷：14
• 期：1
• 页码：10-21
• 全文大小：838 K

文摘

The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.