Activation of GPER suppresses migration and angiogenesis of triple negative breast cancer via inhibition of NF-κB/IL-6 signals

详细信息    查看全文

• 作者：Shuwei Liang^a ; ¹ ; Zhuojia Chen^b ; ¹ ; Guanmin Jiang^c ; Yan Zhou^a ; Qiao Liu^a ; Qiao Su^d ; Weidong Wei^b ; Jun Du^a ; Hongsheng Wang^a ; ^{whongsh@mail.sysu.edu.cn} ; ^{hongshengwang@foxmail.com}
• 关键词：GPER ; G-1 ; Angiogenesis ; TNBC ; NF-κB
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：12-23
• 全文大小：4465 K
• 卷排序：386

文摘

GPER agonist G-1 inhibited IL-6 and VEGF-A in TNBC cells. G-1 or anti-IL-6 suppressed in vitro tube formation of HUVECs. Recombinant IL-6 reversed inhibitory effects of G-1 on angiogenesis and migration. G-1 inhibited the binding of NF-κB with IL-6 promoter. The suppression of IL-6 by G-1 inhibited HIF-1α and STAT3 signals.