Mucosal-associated invariant T cells from patients with tuberculosis exhibit impaired immune response
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- 作者：Jing Jiang ; Bingfen Yang ; Hongjuan An ; Xinjing Wang ; Yanhua Liu ; Zhihong Cao ; Fei Zhai ; Ruo Wang ; Yan Cao ; Xiaoxing Cheng ; xcheng79@outlook.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tuberculosis ; Immune response ; MAIT cells
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：72
- 期：3
- 页码：338-352
- 全文大小：3368 K
文摘
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IFN-γ response of MAIT cells to M. tuberculosis was dramatically improved by IL-15.
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Blockade of γc and IL-2Rβ resulted in highly reduced IFN-γ-producing MAIT cells.
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Patients with active TB exhibited impaired cytokine and cytotoxic responses.