Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke
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- 作者：Honglin Yan&dagger ; ; Jingping Yuan ; &dagger ; ; yuanjingping2003@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Likun Gao ; Jie Rao ; Jichang Hu
- 关键词：CNS ; central nervous system ; ECA ; external carotid artery ; FJ ; Fluoro-Jade C ; ICA ; internal carotid artery ; lncRNA ; long non-coding RNA ; MCA ; middle cerebral artery ; MCAO ; middle cerebral artery occlusion ; MEG3 ; maternally expressed gene 3 ; miRNAs ; microRNAs ; MRI ; magnetic resonance imaging ; OGD ; oxygen glucose deprivation ; PDL ; poly-d-lysine ; PI ; propidium iodide ; PIC ; preinitiation complex ; piRNAs ; piwi-associated RNAs ; qRT-PCR ; quantitative real-time PCR ; RNS ; reactive nitrogen species ; ROS
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：19 November 2016
- 年：2016
- 卷：337
- 期：Complete
- 页码：191-199
- 全文大小：1117 K
文摘
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We first confirmed the expression and function of long noncoding RNA maternally expressed gene 3 (MEG3) in ischemia.
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MEG3 binds with p53-DBD271–282 which stimulates p53-mediated transactivation and mediates ischemic neuronal death.
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Intervention of MEG3–p53 interaction by administration of Tat-p53-DBD271–282 protects against ischemic insults.
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