The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma

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• 作者：Yue Lu^a ; ^b ; Shuangfan Cai^a ; ^b ; Jia Nie^c ; Yangyang Li^c ; Guochao Shi^d ; Jimin Hao^d ; Wenwei Fu^a ; ^b ; Hongsheng Tan^a ; ^b ; Shilin Chen^e ; Bin Li^c ; ^{binli@sibs.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Hongxi Xu^a ; ^b ; ^{xuhongxi88@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：PP2 (PubChem CID ; 4878) ; Dexamethasone (PubChem CID ; 5743)
• 刊名：Biochemical Pharmacology
• 出版年：2016
• 出版时间：15 January 2016
• 年：2016
• 卷：100
• 期：Complete
• 页码：61-72
• 全文大小：3120 K

文摘

Mast cells play an important role in allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. The genus Garcinia of the family Guttiferae is well known as a prolific source of polycyclic polyprenylated acylphloroglucinols and bioactive prenylated xanthones, which exhibit various biological activities including antibacterial, antifungal, anti-inflammatory, antioxidant, and cytotoxic effects. Nujiangexanthone A (N7) is a novel compound isolated from the leaves of Garcinia nujiangensis. In this paper, we sought to determine the anti-allergic and anti-inflammation activity of N7 in vivo and its mechanism in vitro. We found N7 suppressed IgE/Ag induced mast cell activiation, including degranulation and production of cytokines and eicosanoids, through inhibiting Src kinase activity and Syk dependent pathways. N7 inhibited histamine release, prostaglandin D₂ and leukotriene C₄ generation in mast cell dependent passive cutaneous anaphylaxis animal model. We also found N7 inhibited the IL-4, IL-5, IL-13 and IgE levels in ovalbumin-induced asthma model. Histological studies demonstrated that N7 substantially inhibited OVA-induced cellular infiltration and increased mucus production in the lung tissue. Our study reveals the anti-allergic function of N7, thereby suggesting the utility of this compound as a possible novel agent for preventing mast cell-related immediate and delayed allergic diseases.