MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway
详细信息 查看全文
- 作者：Hongyu Shena ; b ; Dandan Wangb ; Liangpeng Lic ; Sujin Yanga ; b ; Xiu Chena ; b ; Siying Zhoub ; d ; Shanliang Zhonge ; Jianhua Zhaoe ; lcjyjhzhao@163.com" class="auth_mail" title="E-mail the corresponding author ; Jinhai Tanga ; b ; njmujhtang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADR ; adriamycin ; miRNA ; microRNA ; UTR ; untranslated region ; PTEN ; phosphatase a tensin homolog deleted on chromosome 10 ; PIP3 ; phosphatidylinositol-3 ; 4 ; 5-triphosphate ; PIP2 ; diphosphate product ; IC50 ; the inhibitory concentration to produce 50% cell death ; FBS ; fetal bovine serum ; NC ; negative control ; PBS ; phosphate-buffered saline ; RT-qPCR ; real-time quantitative polymerase chain reaction assay ; MTT ; 3-[4 ; 5-dimethylthiazol-2-yl]-2 ; 5-diphenyltetrazolium-bromide ; DMSO ; dimethylsulfoxide ; KEGG ; K
- 刊名：Gene
- 出版年：2017
- 出版时间：5 January 2017
- 年：2017
- 卷：596
- 期：Complete
- 页码：110-118
- 全文大小：1393 K
文摘
- class="listitem" id="list_l0005">
- class="label">•
The expression of miR-222 is negatively correlated with FOXO1 expression in breast cancer cells.
- class="label">•
PTEN/Akt/FOXO1 pathway plays an important role in ADR-resistance of breast cancer.
- class="label">•
Inhibition of miR-222 could reverse the ADR-resistance and improve the prognosis of breast cancer patients.