Three-Step Model for Polarized Sorting of KIF17 into Dendrites
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- 作者：Mariella A. Franker1 ; 2 ; Marta Esteves da Silva1 ; 2 ; Roderick P. Tas1 ; 2 ; Elena Tortosa1 ; Yujie Cao1 ; Cá ; tia P. Frias1 ; Anne F.J. Janssen1 ; Phebe S. Wulf1 ; Lukas C. Kapitein1 ; Casper C. Hoogenraad1 ; c.hoogenraad@uu.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：neuron ; transport ; motor protein ; KIF17 ; autoinhibition ; axon initial segment ; dynein
- 刊名：Current Biology
- 出版年：2016
- 出版时间：11 July 2016
- 年：2016
- 卷：26
- 期：13
- 页码：1705-1712
- 全文大小：4044 K
文摘
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Cargo binding relieves autoinhibition of KIF17 in living cells
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KIF17-bound cargo does not autonomously target dendrites
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KIF17-bound cargoes enter the axon but anchor at the AIS
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Dynein redirects KIF17-bound cargo into dendrites