Role of Rho-mediated ROCK-Semaphorin3A signaling pathway in the pathogenesis of Parkinson's disease in a mouse model
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- 作者：Li Qi1 ; Yong-Gang Tang1 ; Lin Wang ; Wei He ; Hong-Hua Pan ; Rong-Rong Nie ; nie_rr@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Yan Can
- 关键词：Rho ; ROCK ; Semaphorin3A ; Parkinson's disease
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：370
- 期：Complete
- 页码：21-26
- 全文大小：555 K
文摘
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Rho and ROCK knockout may reduce the damage by MPTP on mice behavior.
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Rho and ROCK knockout protects dopaminergic neuron from injury.
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Rho and ROCK knockout decreases Rho, ROCK, Sema3A and relevant factor mRNA expression.
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Rho and ROCK knockout reduces Rho, ROCK, Sema3A and relevant factor proteins.
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Rho and ROCK gene can serve as novel therapeutic targets of PD.