- 作者：Prof Christopher J Logothetis ; MDa ; clogothe@mdanderson.org ; Ethan Basch ; MDb ; Arturo Molina ; MDc ; Prof Karim Fizazi ; MDd ; Scott A North ; MDe ; Kim N Chi ; MDf ; Robert J Jones ; MDg ; Oscar B Goodman ; MDh ; Paul N Mainwaring ; MDi ; Cora N Sternberg ; MDj ; Eleni Efstathiou ; MDa ; Dennis D Gagnon ; MAk ; Margaret Rothman ; PhDl ; Yanni Hao ; PhDl ; Cameron S Liu ; PhDc ; Thian S Kheoh ; PhDc ; Christopher M Haqq ; MDc ; Prof Howard I Scher ; MDb ; &dagger ; ; Prof Johann S de Bono ; MDm ; &dagger ;
- 刊名：Lancet Oncology
- 出版年：2012
- 出版时间：December, 2012
- 年：2012
- 卷：13
- 期：12
- 页码：1210-1217
- 全文大小：342 K
Summary
Background
Bone metastases are a major cause of morbidity in metastatic castration-resistant prostate cancer. Abiraterone acetate potently disrupts intracrine androgen receptor signalling pathways implicated in the progression of the disease, including bone metastases. We assessed data for pain control and skeletal-related events prospectively collected as part of the randomised, phase 3 COU-AA-301 trial of abiraterone acetate plus prednisone versus placebo plus prednisone in patients with metastatic castration-resistant prostate cancer after docetaxel chemotherapy.Methods
The COU-AA-301 trial enrolled patients with metastatic castration-resistant prostate cancer in whom one or two lines of chemotherapy (one docetaxel based) had been unsuccessful and who had Eastern Cooperative Oncology Group performance statuses of 2 or less. Pain intensity and interference of pain with daily activities were assessed with the Brief Pain Inventory-Short Form questionnaire at baseline, day 15 of cycle 1, and day 1 of each treatment cycle thereafter until discontinuation. We assessed, with prospectively defined response criteria that incorporated analgesic use, clinically meaningful changes in pain intensity and interference with daily living. We measured time to first occurrence of skeletal-related events, which we defined as pathological fracture, spinal cord compression, palliative radiation to bone, or bone surgery, and regularly assessed them throughout the study. Pain palliation was assessed in patients who had clinically significant baseline pain, whereas all other analyses were done in the overall intention-to-treat population. COU-AA-301 is registered with , number .
Findings
Median follow-up was 20¡¤2 months (IQR 18¡¤4-22¡¤1). In patients with clinically significant pain at baseline, abiraterone acetate and prednisone resulted in significantly more palliation (157 of 349 [45¡¤0 % ] patients vs 47 of 163 [28¡¤8 % ]; p=0¡¤0005) and faster palliation (median time to palliation 5¡¤6 months [95 % CI 3¡¤7-9¡¤2] vs 13¡¤7 months [5¡¤4-not estimable]; p=0¡¤0018) of pain intensity than did prednisone only. Palliation of pain interference (134 of 223 [60¡¤1 % ] vs 38 of 100 [38¡¤0 % ], p=0¡¤0002; median time to palliation of pain interference 1¡¤0 months [95 % CI 0¡¤9-1¡¤9] vs 3¡¤7 months [2¡¤7-not estimable], p=0¡¤0004) and median duration of palliation of pain intensity (4¡¤2 months [95 % CI 3¡¤0-4¡¤9] vs 2¡¤1 months [1¡¤4-3¡¤7]; p=0¡¤0056) were significantly better with abiraterone acetate and prednisone than with prednisone only. In the overall population, median time to occurrence of first skeletal-related event was significantly longer with abiraterone acetate and prednisone than with prednisone only (25¡¤0 months [95 % CI 25¡¤0-not estimable] vs 20¡¤3 months [16¡¤9-not estimable]; p=0¡¤0001).
Interpretation
In patients with metastatic castration-resistant prostate cancer previously treated with docetaxel, abiraterone acetate and prednisone offer significant benefits compared with prednisone alone in terms of pain relief, delayed pain progression, and prevention of skeletal-related events.
Funding
Janssen Research & Development and Janssen Global Services.