Development and validation of a simple and robust HPLC method with UV detection for quantification of the hepatitis C virus inhibitor daclatasvir in human plasma

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• 作者：Giulio Nannetti^a ; Lorenzo Messa^a ; Marta Celegato^a ; Silvana Pagni^a ; ^b ; Monica Basso^a ; ^b ; Saverio G. Parisi^a ; ^b ; Giorgio Palù ; ^a ; ^b ; ¹ ; Arianna Loregian^a ; ^b ; ¹ ; ^{arianna.loregian@unipd.it}
• 关键词：Daclatasvir ; BMS-790052 ; HCV NS5A inhibitor ; Solid-phase extraction ; HPLC-UV ; Therapeutic drug monitoring
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：275-281
• 全文大小：575 K
• 卷排序：134

文摘

The first HPLC-UV method was developed for the determination of DCV in human plasma. This method was applied to quantification of daclatasvir in clinical samples. Daclatasvir is degraded by sunlight.