Maternal exposure to ochratoxin A targets intermediate progenitor cells of hippocampal neurogenesis in rat offspring via cholinergic signal downregulation and oxidative stress responses
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- 作者：Takeshi Tanakaa ; b ; tatanaka@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yasuko Hasegawa-Babaa ; yhase@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yousuke Watanabea ; b ; ywatana@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Sayaka Mizukamia ; b ; smizuka@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yumi Kangawaa ; kangawa_yumi@kaken.co.jp" class="auth_mail" title="E-mail the corresponding author ; Toshinori Yoshidaa ; yoshida7@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Makoto Shibutania ; mshibuta@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotrophic factor ; BW ; body weight ; CALB1 ; calbindin-D-28K ; CALB2 ; calbindin-D-29K ; CHRNB2 ; cholinergic receptor ; nicotinic ; beta 2 (neuronal) ; CT ; threshold cycle ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; DCX ; doublecortin ; GABA ; γ-aminobutyric acid ; Gapdh ; glyceraldehyde 3-phosphate dehydrogenase ; GCL ; granule cell layer ; GD ; gestational day ; GFAP ; glial fibrillary acidic protein ; 4-HNE ; 4-hydroxynonenal ; Hprt1 ; hypoxanthine phosphoribosyltransferase 1 ; MDA ; malondialdehyde ; Neu
- 刊名：Reproductive Toxicology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：113-122
- 全文大小：3203 K
文摘
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Maternal exposure effect of OTA on hippocampal neurogenesis was examined.
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Type-2 progenitor granule cells in the SGZ were reversibly reduced upon weaning.
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Reduced cholinergic signals and increased oxidative stress may affect neurogenesis.
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BDNF increment might be a neuroprotective mechanism for disrupted neurogenesis.
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The NOAEL for offspring neurogenesis was determined to be 39.3–76.0 μg/kg BW/day.