Identification of the key pathway of oxazolinoanthracyclines mechanism of action in cells derived from human solid tumors

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• 作者：Marta Denel-Bobrowska^a ; ^{mdenel@biol.uni.lodz.pl} ; Małgorzata Łukawska^b ; Aneta Rogalska^a ; Ewa Forma^c ; Magdalena Bryś^c ; Irena Oszczapowicz^b ; Agnieszka Marczak^a
• 关键词：BIR ; baculovirus inhibitor of apoptosis protein repeat ; Bcl-2 ; B-cell lymphoma 2 ; CASP3 ; caspase-3 ; CASP9 ; caspase-9 ; CYC2 ; cytochrome c ; DMEM ; Dulbecco's Modified Eagle Medium ; FBS ; fetal bovine serum ; HCC ; human hepatocellular carcinoma ; HPRT1 ; hypoxanthine phosphoribosyltransferase 1 ; IAP ; inhibitor of apoptosis ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; PARP-1 ; poly (ADP-ribose) polymerase 1 ; PI ; propidium iodide ; RIP kinases ; receptor&ndash ; interacting protein kinas
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：313
• 期：Complete
• 页码：159-169
• 全文大小：1740 K
• 卷排序：313

文摘

Substituted amino group increased the anticancer activity of anthracyclines. Mitochondrial apoptotic pathway seems to be involved in the mechanism of action. Favorable biological properties of oxazoline derivatives were confirmed.