Correlation between viral load, multiplicity of infection, and persistence of HPV16 and HPV18 infection in a Dutch cohort of young women
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- 作者：Pascal van der Weelea ; b ; pascalvanderweele@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Elske van Logchema ; Petra Wolffsc ; 1 ; Ingrid van den Broeka ; 2 ; Mariet Feltkampd ; Hester de Melkera ; Chris J.L.M. Meijerb ; Hein Boota ; 3 ; Audrey J. Kinga
- 关键词：HPV16 ; HPV18 ; Persistent infection ; Viral load ; Multiple HPV infection
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：6-11
- 全文大小：545 K
文摘
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Highly sensitive assays for HPV16 and HPV18 quantification are introduced.
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Population level HPV16/18 VL is higher in persisting than clearing infections.
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HPV16/18 load cannot be used to predict infection outcome at individual level.
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HPV16 load is higher in multiple versus single HPV type infections.
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HPV16/18 load might be used as proxy for persistence in vaccine monitoring.