Coxsackievirus B3 induces the formation of autophagosomes in cardiac fibroblasts both in vitro and in vivo
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- 作者：Xia Zhaia ; zhai_xia_cool@126.com" class="auth_mail" title="E-mail the corresponding author ; Ying Qina ; qinyinggaofeng@163.com" class="auth_mail" title="E-mail the corresponding author ; Yang Chena ; cy_hmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Lexun Lina ; linlexun@163.com" class="auth_mail" title="E-mail the corresponding author ; Tianying Wanga ; wangty0929@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoyan Zhonga ; littlerock712@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoyu Wuc ; xiaoyu_wu2006@163.com" class="auth_mail" title="E-mail the corresponding author ; Sijia Chena ; chensj0802@163.com" class="auth_mail" title="E-mail the corresponding author ; Jing Lid ; jing070822@163.com" class="auth_mail" title="E-mail the corresponding author ; Yan Wanga ; wangyan@hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fengmin Zhanga ; fengminzhang@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wenran Zhaob ; zhaowenran2002@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; zhaowr@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhaohua Zhonga ; zhongzh@hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CVB ; coxsackievirus B ; IL ; interleukin ; TNF ; tumor necrosis factor ; IFN ; interferon ; ORF ; open reading frame ; MOI ; multiplicity of infection ; EGFP ; enhanced green fluorescence protein ; LC3 ; microtubule-associated protein 1light chain 3 ; PCR ; polymerase chain reaction ; 3-MA ; 3-methyladenine ; ERK ; extracellular regulated kinase ; MAVS ; mitochondrial antiviral signaling protein ; TRIF ; Toll/IL-1 receptor domain-containing adaptor inducing interferon-beta
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：349
- 期：2
- 页码：255-263
- 全文大小：1687 K
文摘
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CVB3 replication induced autophagosome assembly in primary cardiac fibroblasts.
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Both IL-6 and TNF-α in cardiac fibroblasts infected by CVB3 were increased.
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IL-6 and TNF-α were reduced in cardiac fibroblasts when autophagy was inhibited.
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Autophagosome assembly in cardiac fibroblasts of CVB-infected mice was increased.