Mapping Whole-Transcriptome Splicing in Mouse Hematopoietic Stem Cells

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• 作者：Oron Goldstein¹ ; ² ; Karin Meyer¹ ; Yariv Greenshpan¹ ; ² ; Nir Bujanover¹ ; ² ; Mili Feigin¹ ; Hadas Ner-Gaon³ ; Tal Shay³ ; Roi Gazit¹ ; ² ; ⁴ ; ^{gazitroi@bgu.ac.il}
• 关键词：hematopoietic stem cell ; whole-transcriptome splicing ; alternative splicing ; RNA-sequencing analysis ; HSC ; ImmGen ; unannotated splicing ; splicing-function ; adult stem cell splicing
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：163-176
• 全文大小：3051 K
• 卷排序：8

文摘

This study presents the splicing landscape in mouse hematopoietic stem cells Many HSC genes express multiple isoforms, some with alternative isoforms High-resolution analysis allows the discovery of unannotated splicing HSC-expressed isoforms can have similar or divergent functions