Imidacloprid induces various toxicological effects related to the expression of 3β-HSD, NR5A1, and OGG1 genes in mature and immature rats

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• 作者：Amany Abdel-Rahman Mohamed ; ¹ ; ² ; ^{amanyrahman292@yahoo.com} ; ^{aabdaziz@zu.edu.eg} ; Wafaa A.M. Mohamed¹ ; ² ; Safaa I. Khater
• 关键词：Neonicotinoid ; Spermatogenesis ; Comet ; 8-OHdG ; Bax
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：221
• 期：Complete
• 页码：15-25
• 全文大小：2918 K
• 卷排序：221

文摘

IMI is an insecticide that acts as an agonist of nicotinic acetylcholine receptors. IMI suppressed the spermatogenic and steroidogenic activities and caused DNA damage in rats. IMI induced changes in 3β-HSD, NR5A1, and OGG1 gene expressions and apoptosis in testicular tissue and SV cells. The observed drawbacks were mostly augmented in mature IMI-treated rats compared to their immature counterparts.