Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan

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• 作者：Chih-Yao Chen^a ; ^b ; Yi-Ning Su^a ; Tzu-Hung Lin^a ; Yi Chang^b ; ^c ; Huann-Cheng Horng^b ; ^c ; Peng-Hui Wang^b ; ^c ; ^d ; ^{phwang@vghtpe.gov.tw} ; ^{phwang@ym.edu.tw} ; ^{pongpongwang@gmail.com} ; Chang-Ching Yeh^b ; ^c ; Wen-Hsun Chang^e ; ^f ; Hsin-Yi Huang^g
• 关键词：blood loss ; carbetocin ; cesarean section ; postpartum hemorrhage ; vaginal delivery
• 刊名：Taiwanese Journal of Obstetrics and Gynecology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：55
• 期：6
• 页码：804-809
• 全文大小：440 K
• 卷排序：55

文摘

The aim of this retrospective observational study was to determine the efficacy of carbetocin in reducing blood loss and primary postpartum hemorrhage (PPH) in vaginal and cesarean deliveries in a tertiary hospital in Taiwan.Materials and methodsEligible gravid women (27–41 weeks) with available data were categorized into those treated prophylactically with and without carbetocin. The primary outcome was blood loss and incidence of primary PPH as measured by intrapartum/intraoperative and postpartum (recovery room) blood loss.ResultsA total of 1069 deliveries were evaluated. Maternal age (∼31 years of age), body mass index (∼27 kg/m2) and parity (∼1.4) were similar among those treated with and without carbetocin for both vaginal and cesarean deliveries. The majority [749/1069 (70.1%)] of deliveries were vaginal; a similar proportion of women undergoing vaginal [221/749 (29.5%)] and cesarean [110/320 (34.4%)] deliveries received prophylactic carbetocin for prevention of PPH. Among vaginal deliveries, there was no significant difference in intrapartum (p = 0.083) or postpartum (p = 0.925) blood loss, or incidence of PPH (p = 0.092) between women with versus without carbetocin prophylaxis. However, there was a significant reduction in the intraoperative and total blood loss among cesarean deliveries with versus without carbetocin prophylaxis (p < 0.001). The incidence of PPH was higher [84/320 (26.3%)] among cesarean than among vaginal deliveries [62/749 (8.3%)], but was significantly lower among cesarean deliveries with [18 (16.36%)] versus without [66 (30.45%); p = 0.003] carbetocin prophylaxis.ConclusionIn Taiwan, prophylactic use of carbetocin resulted in significantly less blood loss and incidence of PPH in cesarean than in vaginal deliveries.