Major vault protein regulates cell growth/survival signaling through oxidative modifications
详细信息 查看全文
- 作者：Dividutta Das ; Yi-Hsuan Wang ; Cheng-Ying Hsieh ; Yuichiro J. Suzuki ; ys82@georgetown.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Airway ; Glutathionylation ; Major vault protein ; Myosin-9 ; Redox signaling ; Smooth muscle cells
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：28
- 期：1
- 页码：12-18
- 全文大小：1123 K
文摘
- •
Growth factors promote S-glutathionylation of major vault protein in airway smooth muscle cells.
- •
Major vault protein mediates cell growth and survival.
- •
Myosin-9 interacts with major vault protein in an S-glutathionylation-dependent fashion.
- •
Myosin-9 participates in the cell death mechanism that is induced by heating, but not by hydrogen peroxide.
- •
Glutaredoxin 1 regulates airway smooth muscle cell growth and death.