Leisure activities, apolipoprotein E e4 status, and the risk of dementia

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• 作者：Sheng-Ying Yang^a ; Pei-Hsuan Weng^a ; ^b ; Jen-Hau Chen^c ; Jeng-Min Chiou^d ; Chih-Yin Lew-Ting^e ; Ta-Fu Chen^f ; Yu Sun^g ; Li-Li Wen^h ; Ping-Keung Yipⁱ ; ^j ; Yi-Min Chu^k ; Yen-Ching Chen^a ; ^l ; ^m ; ^{karenchen@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Alzheimer's disease ; apolipoprotein E ; dementia ; leisure activities ; vascular
• 刊名：Journal of the Formosan Medical Association
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：114
• 期：12
• 页码：1216-1224
• 全文大小：311 K

文摘

Leisure activities have been associated with a decreased risk of dementia. However, to date, no study has explored how apolipoprotein E (ApoE) e4 status or vascular risk factors modified the association between leisure activities and dementia risks.

Methods

This case–control study recruited patients (age ≥ 60 years) with Alzheimer's disease (AD; n = 292) and vascular dementia (VaD; n = 144) and healthy controls (n = 506) from three teaching hospitals in Taiwan between 2007 and 2010. Information on patient's leisure activities were obtained through a questionnaire. Conditional logistic regression models were used to assess the association of leisure activities and ApoE e4 status with the risk of dementia.

Results

High-frequency physical activity was associated with a decreased risk of AD [adjusted odds ratio (AOR) = 0.45], and the results become more evident among ApoE e4 carriers with AD (AOR = 0.30) and VaD (AOR = 0.26). Similar findings were observed for cognitive (AOR = 0.42) and social activities (AOR = 0.55) for AD. High-frequency physical, cognitive, and social activities were associated with a decreased risk of VaD (AOR = 0.29–0.60). Physical and social activities significantly interacted with each other on the risk of VaD (p_interaction = 0.04).

Conclusion

Physical activity consistently protects against AD and VaD. Significant interactions were identified across different types of leisure activities in lowering dementia risk.