Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

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• 作者：Siew Cheng Phua¹ ; ^{phua0022@e.ntu.edu.sg} ; Shuhei Chiba² ; Masako Suzuki³ ; Emily Su¹ ; Elle C. Roberson⁴ ; Ganesh V. Pusapati⁶ ; Mitsutoshi Setou⁵ ; Rajat Rohatgi⁶ ; Jeremy F. Reiter⁴ ; Koji Ikegami⁵ ; ^{kikegami@hama-med.ac.jp} ; Takanari Inoue¹ ; ⁷ ; ^{jctinoue@jhmi.edu}
• 关键词：Primary cilia ; decapitation ; disassembly ; cell-cycle entry ; extracellular vesicles ; ectosome ; Inpp5e ; PI(4 ; 5)P2 ; F-actin ; AurA ; Gli ; genetically encoded ciliary actin inhibitor
• 刊名：Cell
• 出版年：2017
• 出版时间：12 January 2017
• 年：2017
• 卷：168
• 期：1-2
• 页码：264-279.e15
• 全文大小：9355 K
• 卷排序：168

文摘

The phosphatase Inpp5e restricts actin polymerization in primary cilia Intraciliary PI(4,5)P2 and F-actin trigger cilia decapitation Cilia decapitation disassembles cilia and drives cell cycle