Stability of Xuesaitong capsules in gastrointestinal lavage fluid

详细信息    查看全文

• 作者：Bing Yang ; Shouying Du ; ^{dushouying@263.net" class="auth_mail" title="E-mail the corresponding author} ; Yang Lu ; ^{landocean28@163.com" class="auth_mail" title="E-mail the corresponding author} ; Pengyu Li ; Chang Yang ; Qing Zhang ; Zhen Wang ; Jie Bai ; Huichao Wu
• 关键词：Xuesaitong capsule ; Panax notoginsenoside ; Gastric lavage fluid ; Stability ; Chinese herbal medicine
• 刊名：Journal of Traditional Chinese Medical Sciences
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：3
• 期：1
• 页码：41-49
• 全文大小：1285 K

文摘

To obtain a formulation with high bioavailability through evaluation of the stability of three types of Xuesaitong capsules in the stomachs and intestines of rats. We compared the stability of the Panax notoginsenoside R₁ as well as the ginsenosides Rg₁, Rb₁, Re, and Rd in different formulations.

Methods

Artificial stomach fluid (ASF) and artificial intestinal fluid (AIF) were prepared. Stability of three types of Xuesaitong capsules was examined for 4 h in stomachs and 24 h in intestines. Samples were analyzed at different times by high-performance liquid chromatography. Percent content of NGR₁, GRg₁, GRb₁, GRe, and GRd at different times was calculated.

Results

Hard capsules incubated in ASF disintegrated within 2–3 min, whereas soft capsules disintegrated within 7–8 min. Components in hard capsules were dissolved rapidly in water, with content of each compound reaching 90% in 5 min, and degradation of each compound reaching 30–50% after incubation for 240 min. Dissolution and degradation of each component in soft capsules with a water-soluble base tended to balance at 30–90 min. Contents in soft capsules with a lipid-soluble base showed slow dissolution after ASF incubation for 120 min. Five saponins in identical types of capsules incubated in ASF had similar stability curves. Contents of hard capsules and soft capsules with a water-soluble base degraded rapidly within 30 min and reached a plateau when Xuesaitong capsules were incubated in AIF.

Conclusions

Contents of capsules with a lipid-soluble base degraded slower than the other two types of capsules incubated in ASF and AIF, suggesting that they may have better bioavailability.