The transcription regulation analysis of Ctenopharyngodon idellus PKR and PKZ genes
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- 作者：Dan Liu ; Huiling Mao ; Meihui Gu ; Xiaowen Xu ; Zhicheng Sun ; Gang Lin ; Haizhou Wang ; Dingkun Xie ; Qunhao Hou ; Xiangqin Wang ; Yichuan Mi ; Xiancheng Liu ; Chengyu Hu ; hucy2008@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATF3 ; Activating transcription factor 3 ; CIK ; Ctenopharyngodon idellus kidney ; CREB ; cAMP-responsive element binding proteins ; DBD ; DNA-binding domain ; EMSA ; gel electrophoretic mobility shift assays ; FCS ; fetal calf serum ; IFN ; interferon ; ISG ; interferon stimulated gene ; ISGF-3 ; interferon-stimulated gene factor 3 ; ISRE ; interferon stimulated response element ; IRF1 ; interferon regulatory factor 1 ; IRF3 ; interferon regulatory factor 3 ; IRF7 ; interferon regulatory factor 7 ; IRF-E ; Interferon reg
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：512-519
- 全文大小：1041 K
文摘
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The expression of CiPKR and CiPKZ were significantly increased following Poly I:C stimulation.
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CiIRF3 bound to the promoters of CiPKR and CiPKZ with high affinity in vitro.
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CiIRF3 was able to up-regulate the transcriptional level of CiPKR and CiPKZ in vivo.
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ISRE was an important component but not the only element in the transcriptional initiation of CiPKR and CiPKZ.