Gold-coated silica-fiber hybrid materials for application in a novel hydrogen peroxide biosensor

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• 作者：Jianhua Shen ; Xiaoling Yang ; ^{xlyang@ecust.edu.cn} ; Yihua Zhu ; ^{yhzhu@ecust.edu.cn} ; Haigang Kang ; Huimin Cao ; Chunzhong Li
• 关键词：K-gold solution ; Gold-coated silica-fiber ; Core&ndash ; shell hybrid nanostructure ; Biosensor ; Horseradish peroxidase ; Hydrogen peroxide
• 刊名：Biosensors and Bioelectronics
• 出版年：2012
• 出版时间：15 April, 2012
• 年：2012
• 卷：34
• 期：1
• 页码：132-136
• 全文大小：866 K

文摘

We describe the preparation and characterization of a novel type of core-shell hybrid material for application in a novel hydrogen peroxide biosensor, where the structure consists of a continuous gold shell that encapsulates the silica fiber. The SiO₂@Au nanofibers had been synthesized by electrospinning silica sol, and then golden seeds were in situ grown on the fiber, lastly the gold-seeded silica fibers were further coated by continuous gold shells. The above nanocomposites had satisfactory chemical stability, excellent biocompatibility and efficient electron transfer property, which may have potential application for the highly sensitive chemical or biological sensors. Cyclic voltammetry (CV) was used to evaluate the electrochemical performance of the SiO₂@Au nanocomposites at indium tin oxide (ITO). The biosensor showed high sensitivity and fast response upon the addition of H₂O₂ and the linear range to H₂O₂ was from 5 ¡Á 10^? to 1.0 ¡Á 10^? M with a detection limit of 2 ¦ÌM (S/N = 3). The apparent Michaelis-Menten constant of the biosensor was 1.11 mmol L^?. These results indicated that SiO₂@Au nanocomposites have potential for constructing of a variety of electrochemical biosensors.