Effects of mycophenolic acid on highly sensitized patients awaiting kidney transplant

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• 作者：Tariq Shah^a ; ^b ; ^c ; ^e ; ¹ ; ² ; Don Vu^b ; ^c ; ^f ; ¹ ; ³ ; Eglis Corrales-Tellez^d ; ⁴ ; James Cicciarelli^f ; ³ ; Ian Hutchinson^e ; ^f ; ³ ; Robert Naraghi^a ; ^b ; ² ; David I. Min^b ; ^c ; ^{dmin@westernu.edu}
• 关键词：MPA ; mycophenolic acid ; PRA ; panel reactive antibody ; FCXM ; flow cytometry crossmatch ; MCS ; mean channel shift ; Cellcept® ; and generics MMF ; mycophenolate mofetil ; EC-MPS Myfortic® ; enteric coated-mycophenolate sodium
• 刊名：Transplant Immunology
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：28
• 期：1
• 页码：32-37
• 全文大小：512 K

文摘

Background

10-30 % of dialysis population awaiting renal transplantation is sensitized. Mycophenolic acid (MPA) has been shown to reduce panel reactive antibody (PRA) formation in kidney transplant recipients. Our aim was to investigate whether MPA could effectively reduce anti-HLA antibody levels and allow successful transplantation.

Methods

A total of 40 highly sensitized patients were treated orally with MPA. All patients had T-cell PRA values greater than 30 % (73 % of patients were ¡Ý 75 % ). The PRAs, T-cell/B-cell flow cytometry crossmatch (FCXM) mean channel shift (MCS), patient/graft survival, acute rejection, and serum creatinine (SCr) were recorded.

Results

All 40 patients showed a decrease in PRA levels. Eighteen of the 40 patients (40 % ) received a transplant. All four living donor recipients converted to a negative crossmatch. There was a significant decrease in FCXM MCS in all 18 transplanted patients. The mean SCr at 24 months was 1.00 ¡À 0.25 mg/dL. Five patients (28 % ) experienced acute rejection. The overall one year actuarial patient and graft survival were 94 % and 88 % , respectively.

Conclusions

These findings suggest that MPA therapy is effective in reducing PRAs and increases the likelihood of successful transplantation in sensitized recipients in a potentially simpler and more cost effective manner than the current regimens employed.