Antibacterial activity of medicinal herb extracts against Salmonella

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• 作者：Mi-Hyang Lee ; Hyun Ae Kwon ; Dong-Yeul Kwon ; Hyun Park ; Dong-Hwan Sohn ; Youn-Chul Kim ; Seong-Kug Eo ; Ho-Young Kang ; Sam-Woong Kim and John Hwa Lee
• 关键词：Antimicrobial activity ; Medicinal herb ; Salmonella ; Schizandrae Fructus
• 刊名：International Journal of Food Microbiology
• 出版年：2006
• 出版时间：1 October 2006
• 年：2006
• 卷：111
• 期：3
• 页码：270-275
• 全文大小：288 K

文摘

The therapeutic potentials of twenty-two medicinal herb species traditionally used in Korea to treat gastrointestinal infections were evaluated for the treatment of salmonellosis. Candidates were primarily screened using the disk-agar method for antibacterial activity against three different Salmonella serotypes. Of the herbs tested, the aqueous and methanolic extracts of Schizandrae Fructus exhibited antibacterial activity against all three Salmonella. The extracts of this herb were further tested against 13 additional Salmonella strains of 6 different serotypes. All of these strains were also affected by these extracts, though the methanolic extract had slightly higher activity. The MIC values of this extract against the 16 Salmonella strains varied from 15.6 to 125 μg/ml. Nine of the 16 strains tested had MIC values of < 31.3 μg/ml for the methanolic extract of Schizandrae Fructus. The in vivo antibacterial activity of Schizandrae Fructus extract was examined in a S. Typhimurium infection mouse model. Mice were initially infected with S. Typhimurium, and then administered with Schizandrae Fructus extract. The extract was found to have major effects on mortality and on the numbers of viable S. Typhimurium recovered from feces. Clinical signs and histological damages were rarely observed in the treated mice, whereas the untreated controls showed clinical signs, e.g., lethargy, and histological damage in the kidney, liver, intestine, and spleen. We conclude that Schizandrae Fructus has the potential to provide an effective treatment for salmonellosis.