Synthesis of pyrazoles from 2-azidoacrylates and hydrazonyl chlorides

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• 作者：Yao Li^a ; Deng Hong^a ; Ping Lu ; ^a ; ^{pinglu@zju.edu.cn"" rel=""nofollow} ; Yanguang Wang ; ^a ; ^{orgwyg@zju.edu.cn"" rel=""nofollow}
• 关键词：2-Azidoacrylates ; Hydrazonyl chlorides ; Pyrazoles ; Cycloaddition
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：10 August 2011
• 年：2011
• 卷：52
• 期：32
• 页码：4161-4163
• 全文大小：362 K

文摘

A regioselective synthesis of 1,3,4,5-tetrasubstituted pyrazoles is established between 2-azidoacrylates and hydrazonyl chlorides in the presence of triethylamine. The yields are moderate (43–73 % ) and a possible mechanism for this transformation is postulated.