Curdlan in fibers as carriers of tetracycline hydrochloride: Controlled release and antibacterial activity
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- 作者：Mehrez E. El-Naggara ; b ; mehrez_chem@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Abdelrahman M. Abdelgawada ; b ; Carlos Salasb ; Orlando J. Rojasb ; c
- 关键词：Curdlan ; Tetracycline hydrochloride ; Antibacterial ; Drug delivery ; Nanofibers ; Electrospinning
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：194-203
- 全文大小：3597 K
文摘
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Curdlan cannot be electrospun alone and it is combined with PEO.
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The incorporation of TCH in crosslinked nanofibers of PEO/CURD resulted in a slight increase in the diameter of nanofibers.
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Release of TCH from electrospun webs indicated that electrospun crosslinked nanofibers gave relatively smooth release of TCH over about 24 h as well as an effective and sustainable inhibition of E. coli growth.