Novel chiral multidentate P3N4-type ligand for asymmetric transfer hydrogenation of aromatic ketones
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- 作者：Meng Tao ; Fang Wu ; Teng Li ; Yan-Yun Li ; yanyunli@xmu.edu.cn ; Jing-Xing Gao
- 关键词：Chiral aminophosphine ligand ; Asymmetric catalysis ; Asymmetric transfer hydrogenation ; Chiral alcohols ; Aromatic ketones
- 刊名：Chinese Chemical Letters
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：28
- 期：1
- 页码：97-100
- 全文大小：500 K
- 卷排序：28
文摘
Novel chiral multidentate P3N4-type ligand has been synthesized and characterized by NMR and HRMS. Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand (R,R,R,R)-3 and IrCl(CO)(PPh3)2 exhibited highly catalytic activity and excellent enantioselectivity under mild conditions, achieving the corresponding chiral alcohols with up to 99% yield and 99% ee.