Design of antibacterial biointerfaces by surface modification of poly (ε-caprolactone) with fusion protein containing hydrophobin and PA-1

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• 作者：Xiangxiang Wang^a ; ¹ ; Jiwei Mao^b ; ¹ ; Yiming Chen^b ; Dongmin Song^a ; Zhendong Gao^a ; Xiuming Zhang^a ; Yanling Bai^a ; Per E.J. Saris^c ; Hui Feng^d ; Haijin Xu^b ; ^{xuhaijin@aliyun.com} ; Mingqiang Qiao^a ; ^{qiaomq@nankai.edu.cn}
• 关键词：Hydrophobin ; Antibacterial ; Pediocin PA-1 ; Poly(ε-caprolactone) ; Medical device
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：255-263
• 全文大小：3333 K
• 卷排序：151

文摘

An active fusion protein consisting of hydrophobin HGFI and pediocin PA-1 was successfully expressed in Saccharomyces cerevisiae. The fusion protein PA-1-HGFI could well preserved the self-assembly property of HGFI and antibacterial activity of PA-1. This fusion protein PA-1-HGFI represents a facile, multifunctional and safe technique for antibacterial surface modification.